Research team

Genomic and Evolution of Microorganisms (GEM)


Laboratory Adaptation and Pathogenicity of Microorganisms UMR5163

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General information on reserch team

Address : LAPM UMR5163 Institut Jean Roget, Campus Santé, Domaine de la Merci

City : La Tronche

Zip code : 38700

Objectives of the team : We use experimental evolution to investigate the ecological and molecular mechanisms underlying the dynamics of bacterial evolutionary processes and phenotypic traits, including diversification, adaptation to various environments, virulence, interactions with host cells, and antibiotic resistance. Molecular, genetic, genomic, statistical, and computer tools are integrated to link mutational events, including large chromosomal rearrangements, and regulatory network dynamics to phenotypic changes during evolutionary time. We develop basic, environmental and medical research, and interdisciplinary collaborations with computer scientists, population geneticists and medical practitioners.

R&D projects accredited by Lyonbiopole and funded

EvoDiv : Evolution towards bacterial adaptive diversification: origin and maintenance during long-term adaptation.

Funding : ANR (ANR 2008 Blanc)

Company role in the project : Leader

R&D projects accredited and funded by FINOVI

PEACE : Parallel Experimental and Computational Evolution of virulence in L. pneumophila

Funding : 2010


First name : Dominique

Last name : Schneider

Position : Team manager

Email :

Phone : +33(0)4 76 63 74 90


First name : Max

Last name : Maurin

Position : direction communication

Email :

Phone : 04 76 76 95 94


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Team information

Number of employees 12
Number of lecturers-researchers 8
Number of post-doctoral associate 2
Number of PhD student 2


Bacteriology, Biostatistics - Bioinformatics, Diagnosis, Epidemiology, Genetic/genomic, Host-pathogens relationships, Multi-drug resistance

Working axis

Research axis

The relationships between genomic changes, regulatory network dynamics and phenotypic plasticity (diversification, adaptation, global expression profiles, virulence, antibiotic resistance) are investigated.

Contact : Schneider Dominique - Tel : 04 76 63 74 90 - Email :

Technological development axis

We develop molecular tools for diagnostic purposes and to detect antibiotic resistant determinants in natural isolates of bacterial pathogens and directly in patient samples. We develop new antibacterial compounds.

Contact : Maurin Max - Tel : 04 76 76 95 94 - Email :

Education axis

We are involved in: - teaching Microbiology in the Bachelor Biology program. - teaching Microbiology, Infectiology and Bacterial evolution in the Biology Master program. We are in charge of the Immunology-Microbiology-Infectiology Master program.

Contact : Schneider Dominique - Tel : 04 76 63 74 90 - Email :

We are involved in teaching Microbiology in the Medical Faculty of Grenoble.

Contact : Maurin Max - Tel : 04 76 76 95 94 - Email :

One of us is the head of the Biology Master at University Joseph Fourier.

Contact : Schneider Dominique - Tel : 04 76 63 74 90 - Email :

Service axis

We offer services that are open to academic and private research groups: access to high security laboratories (security level 3), tests of antibacterial compounds, diagnostic tests for infectious diseases.

Contact : Schneider Dominique - Tel : 04 76 63 74 90 - Email :


Last publications

  • New insights into bacterial adaptive abilities by in vivo and in silico experimental evolution, Hindré et al., Nature Reviews Microbiology, 2012
  • Negative epistasis between beneficial mutations in an evolving bacterial population, Khan et al., Science, 2011
  • Genome evolution and adaptation in a long-term experiment with Escherichia coli, Barrick et al., Nature, 2009
  • Mutation rate dynamics in a bacterial population reflect tension between adaptation and genetic load, Wielgoss et al., Proc Natl Acad Sci USA, 2013.
  • Ecological and evolutionary dynamics of coexisting lineages during a long-term experiment with E. coli, Le Gac et al., Proc Natl Acad Sci USA, 2012.

Intellectual property activities

  • Novel bis-indolic derivatives, a process for preparing the same and their uses as drugs Patent N° 11305963.8 - 2117
  • Novel bis-indolic derivatives, their uses in particular as antibacterials Patent N° 11305964.6 - 2117

Specific public private collaborations

Lenski Richard (Michigan State University, USA); Beslon Guillaume (LIRIS, INRIA, Lyon); Etienne Jérôme and Jarraud Sophie (CNR Légionelle, Lyon); Tenaillon Olivier and Denamur Erick (Inserm U722, Paris); Médigue Claudine (CNS, Génoscope, Evry); Denis Jean-Noël (Department Molecular Chemistry, Grenoble), La Scola Bernard (Urmite, Marseille).


Financial support: ANR (programs Blanc, Génomique, BioSys, EmergenceBio), NRBC-CEA, Finovi, Region Rhône-Alpes, Afsset. Our lab is associated to the National Reference Center for Francisella. Member of the National Comitee of Universities (section 65).